The Top Nerve Health Supplements of 2024

By: DTW Health Advisory Board

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what to avoid?

what to look for?

How to Pick a Good Nerve Support Supplement & Avoid the Junk

With so many options, many of us might still be unclear about what to look for in a quality nerve support supplement. To help cut through the clutter, we have compiled months of research for you, featuring the key ingredients shown in studies to help ease nerve discomfort, promote healthy nerve function, and benefit overall nerve health.

This short guide will help you know what to look for and what to avoid, so you can make an informed decision when it comes to your nerve support needs. We will also list out the top 5 nerve support supplements sold today that we researched so you don't have to.

Let's take a moment to understand precisely how nerve supplements work and why adding them to your daily routine is essential.

Nerve Supplements: What Are They All About?

The reality is that many people may not always be able to determine the actual cause of their nerve discomfort. While there could be a variety of root causes, the likely common factor is that nerve health and function was compromised at some point. There are two major ways nerves can become worn down.

The first way nerves can become worn down can best be described by relating to something we all deal with frequently when your phone charger cord becomes damaged. Like the cord of your phone charger, your nerves have a protective coating that acts similarly to the plastic layer protecting the delicate wires inside. It's called a myelin sheath. If a charger cord is bent or damaged and the plastic layer tears, it can stop your phone from charging or connecting properly. Likewise, if the myelin sheath covering your nerves is worn down, it can lead to numbing, tingling, burning sensations, and overall nerve discomfort and irritation.^3-6

The second most common way poor nerve function can happen is one that people who experience sciatica may be able to relate, which is when nerves get pinched or compressed, leading to nerve irritation.⁷

Nerve support formulas commonly comprise various essential vitamins, minerals, and herbs to support nerve health and help strengthen the nerve's protective myelin sheath coating. A complex of B vitamins and the essential Alpha-lipoic acid (a-lipoic acid or ALA) is a vital in improving nerve function and integrity.^8-10

a great nerve support supplement works to:

Help promote better nerve function¹¹

Help ease discomfort¹²

Support healthy nerve function in feet, legs, fingers, & Hands¹³

Strengthen worn down nerves¹⁴

Strengthen nerve integrity¹⁵

Reinforce the myelin sheath¹⁰

Support mobility & flexibility¹⁶

Help protect nerve & Brain cells¹⁰

Title

4 Things To AVOID

When Buying A Nerve Supplement

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1. cyanocobalamin

Cyanocobalamin is the synthetic version of Vitamin B12 often used in supplements because it's cheaper for companies to produce. However, it's also harder for the body to absorb. Methylcobalamin, on the other hand, is the natural form of B12, and studies have shown it to be the most bioavailable form, meaning it's the easiest for the body to absorb and stays in your system longer than Cyanocobalamin.^17-19So when it comes to finding the best nerve support supplement for your needs, look for formulas that use the Methylcobalamin form of Vitamin B12, and avoid formulas that use Cyanocobalamin.

2. proprietary blends

In reviewing the labels of dozens of nerve support supplement brands, we found that many manufacturers group some of their ingredients into a "proprietary blend." Manufacturers argue that they use these proprietary blends to protect their formulas from competitors. However, a blend allows the brand to hide the amount of a key ingredient is actually in the product. Consumers need to know if the critical ingredient they are paying for has 5mg or 600mg in the product. Giving you the total amount of milligrams of the entire blend provides the consumer no insight into what they are actually paying for. Also, proprietary blends are required to list the ingredients in descending order, the highest amount to the lowest amount, if a key ingredient is listed towards the end, then it may indicate that it might not be in an efficacious amount. To make matters worse, brands can choose to cut costs by changing the amounts used for crucial ingredients in a proprietary blend at any time (you can see this if you look at the order of ingredients and find a switch in the position of critical nutrients), leaving the consumer wondering why a product that used to work for them no longer does. For these reasons alone, we advise you avoid wasting your hard-earned money on nerve support brands that use proprietary blends that down disclose the amount of each ingredient in the blend list.

3. relying on amazon reviews

Research showed that in March 2019, there were 1.8 million new unverified reviews, with an average of 99.6% of them being 5-star reviews.²⁰We can suspect many of these reviews are from people paid to write them. We can also suspect many of these fake reviews inflate the number and overall star rating of a product. When deciding on a supplement that can impact your health, don't just rely on Amazon reviews as they don't always show the true benefits of a product or if that customer actually purchased and used the product.

4. insufficient return policy

All reputable supplement brands will demonstrate they have faith in their products by offering 100% money-back guarantee policy. Some try to complicate their refund policies by placing limitations on what kind of returns they will take. Avoid any brand that does not have, at minimum, a no-questions-asked 90-day money-back guarantee.

Title

Top 4 Criteria For A Quality

Nerve Support Supplement

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When it comes to nerve-supporting formulas, not all are created equal. With thousands of different vitamins, minerals, and herbal plant extracts, only a handful have substantial research supporting nerve health benefits. Below are the four most essential ingredients to consider before deciding which brand is best for your needs.

#1 Alpha Lipoic Acid (ALA)

Alpha-lipoic acid (a-lipoic acid or ALA) is an essential ingredient in a nerve support formula as it is a powerful antioxidant shown in studies to help stimulate nerves and may help regernerate nerve fibers.^21,22A recent 2022 study demonstrated that ALA helps to seek and destrop free radicals, which are known as a primary cause of poor nerve function.²³ Other important benefits of ALA are that it helps regenerate cell-protecting antioxidants and supports nerve signaling pathways, nerve blood flow, and motor signals. Regarding nerve discomfort, researchers at Oregon State University showed that ALA is pivotal in easing nerve-related discomfort, including burning, tingling, and numbing sensations.^24,25 An important aspect is that the studies on ALA used a dosage of at least 600mg per day. Some nerve formulas may contain ALA but may not have enough of it to be effective. We advise looking for a nerve formula that contains at least 600mg of standard ALA per serving, the effective dosage confirmed by scientific clinical studies.

#2 Palmitoylethanolamide (PEA)

PEA is widely regarded as a nerve discomfort-reducing superhero. Our bodies naturally produce PEA in tissue as a protective response to acute inflammation. You can also find PEA in foods like egg yolks. PEA works by increasing the production of endocannabinoids, which bind to cells and help ease discomfort and acute inflammation while simultaneously slowing the release of chemicals that can cause acute nerve inflammation.^26,27 A study published in The Journal of Pain Research showed that PEA helped ease nerve discomfort by an astounding 40-80%.²⁸ And PEA has been shown to do more than just ease nerve discomfort and ease acute inflammation in the nerves and nervous system. It also has neuroprotective properties, meaning it can help protect the brain and nerve cells.²⁹

#3 Boswellia Serrata Gum Resin Extract

Boswellia Serrata Gum Resin Extract, also known as Indian frankincense, has been used for centuries in traditional medicine practices. Recent studies have shown that Boswellia Serrata Gum Resin Extract has several nerve health benefits, including protecting the brain, nerves, and nervous system while demonstrating nerve-supporting properties to help ease nerve-related discomfort.³⁰ Be sure to pick a nerve formula that contains this multi-purpost nerve-supporting nutrient.

#4 Benfotiamine

Vitamin B1, also known as Thiamine, helps keep the nervous system healthy and fuels your nerves. Nerves use a lot of energy but can't store it, so they need a constant supply. Vitamin B1 is crucial in turning carbs into the energy that nerves need to function properly and stay healthy.^31,32

Vitamin B1 also works together with Vitamins B6 and B12 to help, repair, and promote nerve growth and strengthen the myelin sheath.^33,34

However, many people have difficulty absorbing Thiamine, and that's where benfotiamine comes in. Benfotiamine is a more bioavailable form of Vitamin B1, meaning the body can use and absorb it more effectively than thiamine. Plus, it turns into thiamine once inside your body, helping naturally promote optimal Vitamin B1 levels.^35,36

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How We Evaluated Our Nerve
Supplement Recommendations

natural, science-backed ingredients

We looked for natural, clean, science-backed ingredients to support healthy nerve function and brands that didn't include additives or dyes.

dosage

We noticed some brands don't have the required hero ingredient amount to substantiate listed claims and benefits. We looked for brands that included and listed ingredients at the dosage necessary to be clinically impactful.

the most effective forms of added ingredients

We noticed some brands did not utilize the most effective forms of ingredients. We looked for a formula containing forms clinical studies show as the most bioavailable and clinically effective.

2024 Nerve Buying Guide

stonehenge health^®
dynamic nerve

researched & approved

Pros

Contains all four essential ingredients: Vitamin B12 as Methylcobalamin, Vitamin B1 as Benfotiamine, PEA, and Boswellia Serrata Gum Resin Extract

Includes 600mg of Standardized Alpha Lipoic Acid (ALA)

Contains 6 additional nerve-supporting nutrients

Lists exact amounts of all 11 ingredients

Vegetarian Capsules, Gluten, & Sugar-Free

Verified 90-day 100% money-back return policy

Manufactured in the USA with internationally sourced ingredients

Cons

Often out of stock due to high demand

why we approved

Stonehenge Health's Dynamic Nerve tops this recommendation list because it contains all four essential nerve-supporting ingredietns: ALA, PEA, Boswellia Serrata, and the Benfotiamine form of Vitamin B1, plus the bioavailable Methylcobalamin form of Vitamin B12. They have also gone a step further by including six additional nerve-supporting nutrients, including acetyl-L-carnitine and vitamins B2, B6, and B9.

In reviewing dozens of nerve-supporting brands, we found that very few have utilized the proper form of ALA in the correct 600mg dosage which is the amount backed by clinical studies to be effective for nerve health. Not only does Stonehenge Health's Dynamic Nerve check this critical box, but just as importantly, they list the exact amounts of each ingredient in their product so you know exactly what you're getting. We like it when a company is transparent, like Stonehenge Health.

We verified that Stonehenge Health's formula does not contain synthetic fillers or artificial ingredients and uses vegetarian capsules. Stonehenge Health backs its products with a no-questions-asked, 90-day money-back guarantee and is one of the few brands endorsed by a board-certified doctor. We also like that they offer customers discounts on bundles. Click on the link below to see their current specials

*Please refer to the manufacturer’s product website for detailed information.

find out more >

sciatiease

researched

Pros

Title

Contains three of the four essential ingredients: Alpha Lipoic Acid, Vitamin B1 as Benfotiamine, and PEA

Contains Vitamin B12 as Methylcobalamin

Includes a variety of herbs

180-Day Money back guarantee

Manufactured in the USA

Cons

Title

Only half the ALA needed for effective dosage

Does not include Boswellia Serrata Gum Resin Extract

Very expensive considering low dosage of ALA

Requires 4 gelatin capsules per dosage

User complaints of stomach upset

SciatiEase is a popular nerve support brand that has been selling for some time. We were pleased to see the potent dosage of PEA, Benfotiamine form of Vitamin B1, Methylcobalamin form of Vitamin B12, and other nerve-supporting B Vitamins. While this product does contain the standard form of ALA, it only offers 300mg per serving, which is half of the 600mg dosage confirmed for effectiveness by clinical studies. It's also missing the important Boswellia Serrata.

While we applaud SciatiEase's generous 180-day return policy, it's the most expensive of all the products we reviewed, and some consumers have noted that it can be difficult to take since it requires 4 capsules per serving. Complaints of stomach upset may also be related to the large dosage requirement, the number of ingredients, and the use of gelatin capsules instead of consumer-preferred vegetarian capsules.

* Please refer to the manufacturer's product website for detailed information. SciatiEase is a registered trademark of SciatiEase Labs LLC.

find out more >

purehealth research nerve regen

researched

Pros

Title

Contains two of the four essential ingredients: Vitamin B12 as Methylcobalamin and Vitamin B1 as Benfotiamine

One-year return policy

Manufactured in the USA

Cons

Title

Only 150mg of standard ALA

Does not contain Boswellia Serrata Gum Resin Extract

Does not contain PEA

Requires 4 gelatin capsules per dosage

User complaints of heartburn

PureHealth Research Nerve Regen has gained popularity through the company's heavy online advertising. We liked that this formula contains the exact same potent dosage of Benfotiamine and Methylcobalamin that the top-recommended product, Dynamic Nerve, does. However, aside from not including the essential ingredients PEA and Boswellia Serrata, PureHealth Research's formula only offers 150mg of standard Alpha Lipoic Acid (ALA). That equates to 25% of the amount used in clinical studies.

This brand relies on including 150mg of R-ALA, a different form of Alpha Lipoic Acid. Even when you combine this formula's ALA and R-ALA, it only equates to 300mg, which is half the recommended 600mg dose.

Like others on this list, Nerve Regen requires the user to take 4 capsules per serving. Consumers have complained about heartburn, potentially related to the various ingredients in this product's "proprietary blend." We appreciate this brand's generous 1-year return policy.

* Please refer to the manufacturer’s product website for detailed information. Nerve Regen Formula is a registered trademark of Purehealth Research LLC.

find out more >

sciaticare

researched

Pros

Title

Contains Vitamin B12 as Methylcobalamin

Contains Vitamin B1 as Benfotiamine

Cons

Title

Proprietary Blend doesn't list the amount of ALA and Benfotiamine

Does not contain PEA

Does not contain Boswellia

Limited potency of Methylcobalamin

Limited 30-day return policy

Sciaticare contains several key ingredients but fell low on our recommendation list due to its use of a proprietary blend that doesn't clearly list the amount of each ingredient. We were puzzled by Sciaticare's inclusion of both forms of Vitamin B1, Thiamine and Benfotiamine. However, a careful review of their label only reveals the amount of Thiamine, and the Benfotiamine is part of the proprietary blend. We often see this as a marketing technique, allowing a company to leave out the amount of a critical ingredient, this can indicate they may have used a miniscule and ineffective dosage.

We prefer brands that are fully transparent in their ingredient dosages. The question of how much R-ALA remains a mystery as this ingredient is part of their proprietary blend. Giving you the total amount of milligrams of the entire blend provides the consumer no insight into how much R-ALA is in that blend.

Sciaticare does not include either PEA or Boswellia Serrata. The brand only offers consumers a 30-day return period, far shorter than our recommended 90-day minimum return policy.

* Please refer to the manufacturer’s product website for detailed information. Sciaticare is a registered trademark of Vita Sciences LLC.

find out more >

Citations

1. https://www.healthdirect.gov.au/nerve-pain

2. https://www.webmd.com/pain-management/unexplained-nerve-pain-the-mystery-of-neuropathic-pain

3. https://pubmed.ncbi.nlm.nih.gov/10727776/

4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3830599/

5. https://www.nationalmssociety.org/What-is-MS/Definition-of-MS/Myelin

6. https://my.clevelandclinic.org/health/body/22974-myelin-sheath

7. https://www.mountsinai.org/health-library/diseases-conditions/sciatica

8. https://ods.od.nih.gov/factsheets/VitaminB12-HealthProfessional/

9. https://www.urmc.rochester.edu/encyclopedia/content.aspx?contentid=AlphalipoicAci &contenttypeid=19

10. https://www.healthline.com/nutrition/alpha-lipoic-acid#what-it-is

11. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930825/

12. https://pubmed.ncbi.nlm.nih.gov/17272797/

13. https://restorativemedicine.org/library/monographs/alpha-lipoic-acid/

14. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8294980/

15. https://www.frontiersin.org/articles/10.3389/fphar.2019.00406/full

16. Prasad S et al CRC Press/Taylor & Francis; 2011. Chap 13.

17. https://www.healthline.com/nutrition/methylcobalamin-vs-cyanocobalamin

18. https://www.justvitamins.co.uk/blog/cyanocobalamin-versus-methylcobalamin/

19. https://pubmed.ncbi.nlm.nih.gov/4696188/

20. https://reviewmeta.com/blog/amazon-flooded-with-millions-of-fake-reviews-in-2019/.

21. https://pubmed.ncbi.nlm.nih.gov/33614362/

22. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021160/

23. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9774895/

24. https://lpi.oregonstate.edu/mic/dietary-factors/lipoic-acid

25. https://pubmed.ncbi.nlm.nih.gov/17065669/

26. https://www.webmd.com/vitamins/ai/ingredientmono-1596/palmitoylethanolamide-pea

27. https://www.iherb.com/blog/pea-palmitoylethanolamide-health-benefits/1652

28. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500919/

29. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157570/

30. https://ppj.phypha.ir/article-1-1739-en.pdf

31. https://www.neurobion.com/en-ph/nerve-health/b-vitamins/b1-b6-b12-vitamins-for-healthy-nervous-system

32. https://www.medicalnewstoday.com/articles/219545

33. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8294980/

34. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930825/

35.https://www.researchgate.net/publication/259627300_Pharmacokinetic_Study_of_Benfotiamine_and_the_Bioavailability_Assessment_Compared_to_Thiamine_Hydrochloride

36. https://www.lifeextension.com/wellness/supplements/benfotiamine-vs-thiamine

The Top Nerve Health Supplements of 2024

How to Pick a Good Nerve Support Supplement & Avoid the Junk

Nerve Supplements: What Are They All About?

a great nerve support supplement works to:

4 Things To AVOID

When Buying A Nerve Supplement

1. cyanocobalamin

2. proprietary blends

3. relying on amazon reviews

4. insufficient return policy

Top 4 Criteria For A Quality

Nerve Support Supplement

#1 Alpha Lipoic Acid (ALA)

#2 Palmitoylethanolamide (PEA)

#3 Boswellia Serrata Gum Resin Extract

#4 Benfotiamine

How We Evaluated Our Nerve Supplement Recommendations

natural, science-backed ingredients

dosage

the most effective forms of added ingredients

2024 Nerve Buying Guide

Pros

Cons

why we approved

Pros

Cons

Pros

Cons

Pros

Cons

How We Evaluated Our Nerve
Supplement Recommendations